DIAGNOSTIC CRITERIA FOR NF2

Confirmed (definite) NF2:

  1. Bilateral vestibular schwannomas (VS) (also known as acoustic neuroma)

Presumptive (probable) NF2:

  1. Family history of NF2 (first degree family relative) plus:
  2. Unilateral VS or any two of the following: meningioma, glioma, schwannoma, juvenile posterior subcapsular lenticular opacity, juvenile cortical cataract

Individuals with the following clinical features should be evaluated for NF2:

  1. Unilateral VS plus at least two of any of the following: meningioma, glioma, schwannoma, juvenile posterior subcapsular lenticular opacities/juvenile cortical cataract
  2. Multiple meningiomas (2 or more) plus unilateral VS or any two of the following: glioma, schwannoma, juvenile posterior subcapsular lenticular opacities/juvenile cortical cataract

Effects of NF2

Neurofibromatosis type 2 (NF-2) is an autosomal dominant genetic disorder that causes tumors to form on the nerves of the central nervous system, in the brain, and on the spine. It affects one in 33,000-40,000 males and females of all races and ethnic groups. The NF-2 gene is located on chromosome 22.

Effects of nf 2
Download a printable PDF of the NF-2 body image

NF-2 Links

NF2 Crew

The NF2Crew is a discussion group for individuals with Neurofibromatosis Type 2, their spouses, significant others, and/or children.

Advocure

A working advocacy group for the NF2 Crew.

Genetic Testing for NF2

Identifies labs in the US which perform this testing.

House Ear Institute

Offers a good FAQ page regarding NF2.

Understanding NF2

A very helpful page from the Advocure site, including detailed images as well as text.

Acoustic Neuroma Association

A patient member organization, providing information and support to persons diagnosed with or treated for acoustic neuroma and other benign tumors of the cranial nerves

Do hormonal contraceptives stimulate growth of neurofibromas?

Marge Lammert, Victor-Felix Mautner, and Lan Kluwe

Evans DGR et al.: Paediatric presentation of type 2 neurofibromatosis.

Informative article about NF2 in children.

Prigatano GP: Preparing patients for possible neuropsychological consequences after brain surgery. BNI Quarterly 11(4): 4-9, 1996

Educational pamphlet at end of article, “Neuropsychological Symptoms After Brain Surgery”